(Terán & Berlandier) I. M. Johnston, Contr. Gray Herb. 70:88. (1924)

Synonyms: Cactus bicolor, Echinocactus setispinus, Ferocactus setispinus, Hamatocactus setispinus, Thelocactus setispinus
Distribution: The distribution area of H. bicolor​​ extends over the southern part of Texas, arriving in the Mexican states of Tamaulipas, Nuevo Leon and Coahuila.
Habitat: H. bicolor colonizing plains ranging from s.l. up to 1000m above s.l. and are characterized by high variability